Michele I Saunders MBBS, MD, FRCR, FRCP Consultant Oncologist,
   Windeyer Professor of Oncology University College London
Education
Royal Free Hospital School of Medicine 1962 – 1967
Training Registrar in Oncology,
Middlesex Hospitals/Mount Vernon Hospitals/St Bartholomew’s Hospital  1970 – 1977

Clinical appointments
Consultant in Radiotherapy and Oncology, Mount Vernon Hospitals 1977 – 2003
Windeyer Professor of Oncology, University College London 2003 -

Academic appointments
Honorary Senior Lecturer, University College & Middlesex School of Medicine 1988 – 1992
Reader in Oncology in Department of Clinical Oncology, University College London 1992 – 1997
Professor in Clinical Oncology, University College London 1997 – 2003
Windeyer Professor of Oncology, University College London 2003 –

Research appointments
Director of Cancer Research UK Tumour Biology and Radiation Therapy Group 1992 –
3 programme grants achieved 1994, 1999, 2004

Areas of interest
Radiation therapy with particular interest in fractionation
Radiobiology
Functional imaging and radiotherapy planning
Molecular genetics
Head and neck cancer
Lung cancer

My main area of research over many years has focused on improving the outcomes of radiation treatment in all patients with cancer.  For the past 20 years my main areas of clinical research have been in head and neck cancer and lung cancer.    My Group was instrumental in introducing hypoxic cell radiosensitisers to clinical practice leading major phase III randomised studies.  Following basic research in collaboration with the Gray Cancer Institute we demonstrated that proliferation was an important cause of cancer failure and this led to investigations into altered fractionation techniques culminating in the randomised controlled trials of conventional radiotherapy versus an accelerated radiotherapy called CHART in non-small cell lung cancer and head and neck cancer.  These trials showed that proliferation was an important cause of failure to cure and in non-small cell lung cancer was significantly superior in terms of survival such that CHART has been recommended as the radiotherapy treatment of choice in early stage non-small cell lung cancer unsuitable for surgery.

Our current interest lies once again in attempting to improve the outcome of radiotherapy and this time returning to the subject of hypoxia but in our current research we are attempting to image hypoxia using novel tracers and PET imaging together with magnetic resonance imaging using BOLD and dynamic contrast sequences.  This research is currently underway with the aim of delineating areas of hypoxia which are radio-resistant and can then be targeted with radiotherapy using the new technological advances incorporated into intensity modulated radiotherapy.

Our Group has for a long time been interested in the molecular profiling of tumours and we have had the opportunity to investigate the epidermal growth factor receptor and its over expression in head and neck cancer.  Using the CHART trials we have been able to show that patients whose tumour expressed EGFR respond better to an accelerated form of radiotherapy rather than conventional radiotherapy but that conventional does not prejudice their outcome.

Plans for the future include co-operation with the Nuclear Medicine Department at University College, Mount Vernon Hospital and King’s College in an effort to validate the novel hypoxia marker Cu64 ATSM and thus hopefully increase the knowledge as to the biology of tumours and their response to radiotherapy.

Prizes and Lectureships
1992 Lennon Award, South African Society for Radiation Therapy
1996 Mackenzie Davidson Lecture and Medal, British Institute of Radiology
         Finzi Lecture and Medal, Oncology Section, Royal Society of Medicine
1997 Glyn Evans Memorial Lecture and Medal, Royal College of Radiologists
1998 Raymond Bush Visiting Professor, Toronto University
1999 Honorary Member, Belgian Society of Radiation Oncology
         Papillon Medal, Lyon
2000 President’s Medal, Royal College of Radiologists
2001 Frank Ellis Medal, Royal College of Radiologists
Contact Us
UCH Head and Neck Services
If you have any questions, please contact us at University College Hospital.

Postal address

Head and Neck Services,
First Floor East 250,
Euston Road,
London NW1 2PG

Telephone via Departmental Secretariat

Sally Zalita    020 7380 9755
Jill Wellard    020 7380 6949
Marlene Bell  020 7380 9859
Allied Health Professionals 020 7380 6948

Your message will be taken and passed on to the appropriate person or department.

e-mail headandneckcentre@uclh.nhs.uk

Fax referrals  020 7380 6952
Links
Cancer Backup (Cancer Information Website)
http://www.cancerbackup.org.uk/Cancertype/Larynx
http://www.cancerbackup.org.uk/Cancertype/Headneck
0808 800 1234   (freephone helpline)

Changing Faces
http://www.changingfaces.co.uk

The Health Professions Council
http://www.hpc-uk.org  

National Association of Laryngectomee Clubs   http://www.nalc.ik.com/  

Macmillan
http://www.macmillan.org.uk

Macmillan CancerLine
0808 808 2020
Copyright UCLH 2008
Sponsored by B. Braun Medical Ltd.